Author

S. Sahakijpijarn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 4 Organism:mouse· 2 Research Focus:phylogenetics / evolution· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Organism:rat· 1

Frequent Co-Authors

R. O. Williams· 8 shared C. Moon· 7 shared Z. Cui· 5 shared D. J. Christensen· 4 shared H. Xu· 4 shared J. J. Koleng· 3 shared C. Cano· 2 shared H. M. Dao· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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8 shared papersPharmacology & Toxicology

R. O. Williams

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8 papers

Recent·Most cited

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

Y.-S. Yu, H. Xu, K. AboulFotouh, G. Williams, J. Suman, S. Sahakijpijarn, C. Cano, Z. Warnken, K. C.- W. Wu, R. O. Williams, Z. Cui

This paper demonstrates the feasibility of intranasally delivering monoclonal antibodies as dry powders using thin-film freeze-drying and the UDS Powder Nasal Spray System.

bioRxiv · Oct 23, 2023 · PreprintPharmacology & Toxicology

Aerosolizable plasmid DNA dry powders engineered by thin-film freezing

H. Xu, C. Moon, S. Sahakijpijarn, H. M. Dao, R. F. Alzhrani, J.-l. Wang, R. O. Williams, Z. Cui

This study tests thin-film freezing to create aerosolizable plasmid DNA dry powders for pulmonary delivery, finding good aerosol performance and preserved pDNA integrity.

bioRxiv · Oct 3, 2022Pharmacology & Toxicology

Degradation of lactoferrin caused by droplet atomization process via two fluid nozzle: The detrimental effect of air water interfaces

H. M. Dao, S. Sahakijpijarn, R. R. Chrostowski, C. Moon, F. Mangolini, Z. Cui, R. O. Williams

This study investigates how the droplet atomization process in spray freeze-drying affects lactoferrin stability, finding that high air-water interfaces cause conformational changes and aggregation.

bioRxiv · Dec 6, 2021 · PreprintPharmacology & Toxicology

Dry Powders for Inhalation Containing Monoclonal Antibodies Made by Thin-Film Freeze-Drying

S. Hufnagel, H. Xu, S. Sahakijpijarn, C. Moon, L. Q. M. Chow, R. O. Williams, Z. Cui

This paper demonstrates that thin-film freeze-drying produces stable aerosolizable dry powders of monoclonal antibodies for pulmonary delivery.

bioRxiv · Oct 29, 2021Pharmacology & Toxicology

Formulation of Dry Powders of Vaccines Containing MF59 or AddaVax by Thin-Film Freeze-Drying

K. AboulFotouh, N. Uno, H. Xu, C. Moon, S. Sahakijpijarn, D. J. Christensen, G. J. Davenport, C. Cano, T. M. Ross, R. O. Williams, Z. Cui

This study demonstrates that thin-film freeze-drying can convert MF59 or AddaVax-adjuvanted vaccines into dry powders while preserving immunogenicity and stability.

bioRxiv · Oct 21, 2021 · PreprintPharmacology & Toxicology

Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in Rats and Hamsters

M. O. Jara, Z. N. Warnken, S. Sahakijpijarn, C. Moon, E. Y. Maier, D. J. Christensen, J. J. Koleng, J. I. Peters, S. D. Hackman, R. O. Williams

This paper develops a niclosamide inhalation powder using thin-film freezing and tests its pharmacokinetics and toxicity in rats and hamsters for COVID-19 treatment.

bioRxiv · Jan 26, 2021 · PreprintPharmacology & Toxicology

In Vivo Pharmacokinetic Study of Remdesivir Dry Powder for Inhalation in Hamsters

s. sahakijpijarn, C. Moon, Z. N. Warnken, E. Maier, J. E. DeVore, D. J. Christensen, J. J. Koleng, R. O. Williams

This study evaluates the pharmacokinetics of remdesivir dry powder for inhalation in hamsters, showing higher drug levels and suggesting a twice-daily dosing regimen.

bioRxiv · Dec 22, 2020Pharmacology & Toxicology

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

S. Sahakijpijarn, C. Moon, J. J. Koleng, D. J. Christensen, R. O. Williams

This paper develops a dry powder formulation of remdesivir for inhalation using thin film freezing, showing improved aerosol performance and lung delivery.

bioRxiv · Jul 26, 2020Pharmacology & Toxicology