NOTCH-mediated non-cell autonomous regulation of chromatinstructure during senescence
A. J. Parry, M. Hoare, D. Bihary, R. Hänsel-Hertsch, S. Smith, K. Tomimatsu, S. Balasubramanian, H. Kimura, S. Samarajiwa, M. Narita
This study shows NOTCH signaling modulates chromatin structure both autonomously and non-autonomously in senescent cells through the JAG1-NOTCH-HMGA1 axis.
bioRxiv · Nov 2, 2017Cell Biology