M. Hoare

Formylation facilitates the reduction of oxidized initiator methionines

This study shows that formylation of initiator methionines enhances their enzymatic reduction and mitigates oxidation-related misprocessing.

Proteome birthdating reveals age-selectivity of protein ubiquitination

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

Methionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry

This paper introduces MObBa, a mass spectrometry method to quantify methionine oxidation by alkylating unoxidized methionines, enabling accurate measurement of oxidation levels in peptides and proteomes.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

Multimodal decoding of human liver regeneration

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry

This study uses mass spectrometry to measure how ribosome binding affects the folding stability of nascent polypeptides, finding that ribosome-induced stability changes depend on localized charge distributions.

LGR5 targeting molecules as therapeutic agents for multiple cancer types

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium

The paper studies clonal hepatocyte expansions in normal human livers, finding a periportal progenitor niche and slow clonal expansion dynamics.

NOTCH-mediated non-cell autonomous regulation of chromatinstructure during senescence

This study shows NOTCH signaling modulates chromatin structure both autonomously and non-autonomously in senescent cells through the JAG1-NOTCH-HMGA1 axis.