R. Bao

Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation

The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.

Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma

This study identifies 11 oncogenic pathways associated with immune exclusion and ICI resistance in acral melanoma, suggesting therapeutic targets for immunotherapy combinations.

Optical Control of G-Actin with a Photoswitchable Latrunculin

This paper introduces OptoLat, a photoswitchable latrunculin that controls G-actin dynamics optically, showing its effects on actin polymerization in various cell types and tissues.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade

This paper shows that BET inhibition makes immunologically cold Rb-deficient prostate cancer more responsive to immune checkpoint blockade by reprogramming the tumor microenvironment through STING/NF-κB/IFN signaling.

Virtual meetings promise to eliminate the geographical and administrative barriers and increase accessibility, diversity, and inclusivity

This study examines the impact of virtual academic conferences during the COVID-19 pandemic, finding increased participation from underrepresented groups but also challenges in engagement and interaction, suggesting a hybrid format is preferable.

Isolation and characterization of novel phages targeting pathogenic Klebsiella pneumoniae

This study isolates and characterizes three phages targeting MDR Klebsiella pneumoniae isolates, showing their lytic potential but also the emergence of phage-resistant mutants.

The Detection of Bergeyella zoohelcum in Young Children after Cat Bite

This paper reports the isolation and identification of Bergeyella zoohelcum from a cat-bite infected child, highlighting challenges in its detection and the importance of advanced techniques.

Antifungal activity of Propranolol against Fusarium keratitis isolates from the Mycotic Ulcer Treatment Trial (MUTT) and the United States.

This study evaluates the antifungal activity of propranolol and its enantiomers against Fusarium keratitis isolates and Aspergillus fumigatus, finding fungicidal effects and reduced MIC with natamycin.

Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types

Inhibiting Mycobacterium tuberculosis ClpP1P2 by addressing the equatorial handle domain of ClpP1 subunit

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.