Author

P. Cieplak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

I. T. Foe· 2 shared J. Z. Long· 2 shared M. Bogyo· 2 shared O. Onguka· 2 shared S. M. Terrell· 2 shared A. Cheltsov· 1 shared A. L. Engelbrektson· 1 shared A. Remacle· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

I. T. Foe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

DUAL FUNCTION OF ZIKA VIRUS NS2B-NS3 PROTEASE

S. Shiryaev, P. Cieplak, A. Cheltsov, R. C. Liddington, A. Terskikh

This study identifies a novel RNA-binding function of ZIKV NS2B-NS3pro, showing that RNA binding occurs in the open conformation and is inhibited in the closed conformation.

PLOS Pathogens · Nov 27, 2023Peer-reviewedImmunology

Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host

O. Onguka, B. M. Babin, M. Lakemeyer, I. T. Foe, N. Amara, S. M. Terrell, K. M. Lum, P. Cieplak, M. J. Niphakis, J. Z. Long, M. Bogyo

This study identifies serine hydrolases in Toxoplasma gondii that hydrolyze lipid esters, showing their role in lipid metabolism and potential as therapeutic targets.

bioRxiv · Nov 24, 2020Microbiology

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

J. T. Ladner, S. N. Henson, A. S. Boyle, A. L. Engelbrektson, Z. W. Fink, F. Rahee, J. D'ambrozio, K. E. Schaecher, M. Stone, W. Dong, S. Dadwal, J. Yu, M. A. Caligiuri, P. Cieplak, M. Bjoras, , J. A. Altin

This study uses PepSeq to map SARS-CoV-2 antibody epitopes and identifies cross-reactivity with hCoV-OC43.

bioRxiv · Jul 27, 2020Immunology

Quantitative profiling of protease specificity.

B. I. Ratnikov, P. Cieplak, A. Remacle, E. Nguyen, J. W. Smith

The paper develops a method to quantitatively profile protease specificity using selectome analysis, substrate phage display, and next-generation sequencing to distinguish between closely related proteases.

bioRxiv · Jun 30, 2020Biochemistry

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

E. Yoo, C. J. Schulze, B. H. Stokes, O. Onguka, T. Yeo, S. Mok, N. F. Gnadig, Y. Zhou, K. Kurita, I. T. Foe, S. M. Terrell, M. J. Boucher, P. Cieplak, R. G. Linington, J. Z. Long, , M. Bogyo

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

bioRxiv · Nov 1, 2019Cell Biology