Author

S. Spudich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

J. Chiarella· 3 shared A. Casanovas-Massana· 1 shared A. Dravid· 1 shared A. Duerr· 1 shared A. Iwasaki· 1 shared A. Ko· 1 shared A. Ring· 1 shared A. Yilmaz· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

J. Chiarella

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Author profile →

4 papers

Recent·Most cited

Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection

Z. Hu, P. Cinque, A. Dravid, L. Hagberg, A. Yilmaz, H. Zetterberg, D. Fuchs, J. Gostner, K. Blennow, S. Spudich, L. Kincer, S. Zhou, S. B. Joseph, R. Swanstrom, R. W. Price, M. Gisslen

The paper measures CSF proteins in HIV-1 infected and uninfected individuals, identifying patterns of protein changes associated with CNS injury and treatment effects.

bioRxiv · May 3, 2024Microbiology

Single-cell immune profiling reveals the impact of antiretroviral therapy on HIV-1-induced immune dysfunction, T cell clonal expansion, and HIV-1 persistence in vivo

J. A. Collora, D. Pinto-Santini, S. Pasalar, N. Ravindra, C. Ganoza, J. Lama, R. Alfaro, J. Chiarella, S. Spudich, D. van Dijk, A. Duerr, Y.-C. Ho

The paper uses single-cell profiling to show that immediate ART partially reverses HIV-1 immune dysfunction but does not eliminate persistent HIV-1 RNA+ cells and their clonal expansion.

bioRxiv · Jan 27, 2021 · PreprintImmunology

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

E. Song, C. M. Bartley, R. D. Chow, T. Ngo, R. Jiang, C. R. Zamecnik, R. Dandekar, R. Loudermilk, Y. Dai, F. Liu, I. Hawes, B. D. Alvarenga, T. Huynh, L. McAlpine, N.-T. Rahman, , S. F. Farhadian

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

bioRxiv · Sep 11, 2020Immunology

Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIV

S. Farhadian, S. Mehta, C. Zografou, J. Pappalardo, J. Chiarella, D. Hafler, S. Spudich

The paper uses scRNA-seq on cerebrospinal fluid from HIV patients to identify a rare microglia-like cell type associated with CNS immune activation.

bioRxiv · May 17, 2018Immunology