Author

R. D. Chow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 6 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Approach:genetic perturbation / CRISPR· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

S. Chen· 6 shared C. B. Wilen· 3 shared A. Iwasaki· 2 shared B. Israelow· 2 shared E. He· 2 shared E. Song· 2 shared F. Zhang· 2 shared G. Wang· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersImmunology

S. Chen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Multiplexed inhibition of immunosuppressive genes with Cas13d for on-demand combinatorial cancer immunotherapy

F. Zhang, G. Wang, R. D. Chow, E. He, M. Majety, Y. Zhang, S. Chen

This paper develops MUCIG, a CRISPR-Cas13d-based method to silence multiple immunosuppressive genes in the tumor microenvironment, showing efficacy in preclinical models.

bioRxiv · Mar 14, 2023Immunology

Perturbomics of tumor-infiltrating NK cells

L. Peng, P. A. Renauer, L. Ye, L. Yang, J. J. Park, R. D. Chow, Y. Zhang, Q. Lin, M. Bai, A. Sanchez, Y. Zhang, S. Z. Lam, S. Chen

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

bioRxiv · Mar 14, 2023 · PreprintImmunology

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

X. Zhou, H. Cao, S.-Y. Fang, R. D. Chow, K. Tang, M. Majety, M. Bai, M. B. Dong, P. A. Renauer, X. Shang, K. Suzuki, A. Levchenko, S. Chen

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

bioRxiv · Mar 14, 2023 · PreprintImmunology

Rational design of immune gene therapy combinations via in vivo CRISPR activation screen of tumor microenvironment modulators

G. Wang, F. Zhang, R. D. Chow, E. He, L. Zhu, Q. Han, S. Chen

This study uses in vivo CRISPR activation screens to identify immunostimulatory factors that enhance anti-tumor immunity and develop effective gene therapy combinations.

bioRxiv · Mar 14, 2023 · PreprintImmunology

LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans

J. Song, R. D. Chow, M. Pena-Hernandez, L. Zhang, S. A. Loeb, E.-Y. So, O. D. Liang, C. B. Wilen, S. Lee

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

bioRxiv · Nov 23, 2021 · PreprintMicrobiology

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

J. S. Chen, R. D. Chow, E. Song, T. Mao, B. Israelow, K. Kamath, J. Bozekowski, W. A. Haynes, R. B. Filler, B. L. Menasche, J. Wei, M. M. Alfajaro, W. Song, L. Peng, L. Carter, , S. C. Eisenbarth

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

bioRxiv · Jun 10, 2021Immunology

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication

J. S. Chen, M. M. Alfajaro, J. Wei, R. D. Chow, R. B. Filler, S. C. Eisenbarth, C. B. Wilen

This study investigates the effect of NSAIDs on SARS-CoV-2 infection and finds that COX-2 is induced by the virus but NSAIDs do not impact viral entry or replication.

bioRxiv · Sep 24, 2020 · PreprintMicrobiology

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

E. Song, C. M. Bartley, R. D. Chow, T. Ngo, R. Jiang, C. R. Zamecnik, R. Dandekar, R. Loudermilk, Y. Dai, F. Liu, I. Hawes, B. D. Alvarenga, T. Huynh, L. McAlpine, N.-T. Rahman, , S. F. Farhadian

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

bioRxiv · Sep 11, 2020Immunology

pegFinder: A pegRNA designer for CRISPR prime editing

R. D. Chow, S. Chen

pegFinder is a web tool that designs prime editing guide RNAs (pegRNAs) for CRISPR prime editing, offering alternative templates and secondary nicking sgRNAs to improve efficiency.

bioRxiv · May 6, 2020 · PreprintBioengineering