Endothelial Nitric Oxide Synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation
T. D. Nguyen, N.-T. Rahman, B. Sessa, M. Y. Lee
This study shows that phosphorylation of eNOS at S1176 by Akt determines atherosclerotic lesion formation, with phospho-mimic mutants reducing plaque while unphosphorylatable mutants increase it.
bioRxiv · Jan 13, 2022Physiology