Author

S. Sugiman-Marangos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Organism:mouse· 1

Frequent Co-Authors

G. L. Beilhartz· 2 shared B. A. Minassian· 1 shared D. Zhou· 1 shared E. Mei· 1 shared J. M. Rini· 1 shared M. Taipale· 1 shared P. K. Kim· 1 shared R. A. Melnyk· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

G. L. Beilhartz

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2 papers

Recent·Most cited

Enhanced delivery of protein therapeutics with a diphtheria toxin-like platform that evades pre-existing neutralizing immunity

S. Gill, S. Sugiman-Marangos, G. L. Beilhartz, E. Mei, M. Taipale, R. Melnyk

This paper identifies a diphtheria toxin homolog from Austwickia chelonae that evades pre-existing anti-DT antibodies and shows improved cargo delivery compared to diphtheria toxin.

bioRxiv · Apr 2, 2024 · PreprintBiochemistry

Exploiting toxin internalization receptors to enhance delivery of proteins to lysosomes for enzyme replacement therapy

S. Sugiman-Marangos, G. L. Beilhartz, X. Zhao, D. Zhou, R. Hua, P. K. Kim, J. M. Rini, B. A. Minassian, R. A. Melnyk

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

bioRxiv · Jan 22, 2020Pharmacology & Toxicology