Author

J. M. Rini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Z. Li· 3 shared S. Mubareka· 2 shared A. J. McGeer· 1 shared A. P. Dupuis· 1 shared A.-C. Gingras· 1 shared B. A. Minassian· 1 shared B. Boon· 1 shared B. Rathod· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Z. Li

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intranasal HD-Ad Vaccine Protects the Upper and Lower Respiratory Tracts of hACE2 Mice against SARS-CoV-2

H. Cao, J. Mai, Z. Zhou, Z. Li, R. Duan, J. Watt, Z. Chen, R. A. Bandara, M. Li, S. K. Ahn, B. Boon, N. Christie, S. Gray-Owen, R. Kozak, S. Mubareka, , J. Liu

bioRxiv · Apr 8, 2021Microbiology

A simple protein-based surrogate neutralization assay for SARS-CoV-2

K. T. Abe, Z. Li, R. Samson, P. Samavarchi-Tehrani, E. J. Valcourt, H. Wood, P. Budylowski, A. P. Dupuis, R. C. Girardin, B. Rathod, K. Colwill, A. J. McGeer, S. Mubareka, J. L. Gommerman, Y. Durocher, , A.-C. Gingras

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

bioRxiv · Jul 10, 2020Immunology

Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells

S. Miersch, M. Ustav, Z. Li, J. B. Case, S. Ganaie, G. Matusali, F. Colavita, D. Lapa, M. R. Capobianchi, G. Novelli, J. B. Gupta, S. Jain, P. P. Pandolfi, M. S. Diamond, G. Amarasinghe, , S. S. Sidhu

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

bioRxiv · Jun 5, 2020 · PreprintBiochemistry

Exploiting toxin internalization receptors to enhance delivery of proteins to lysosomes for enzyme replacement therapy

S. Sugiman-Marangos, G. L. Beilhartz, X. Zhao, D. Zhou, R. Hua, P. K. Kim, J. M. Rini, B. A. Minassian, R. A. Melnyk

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

bioRxiv · Jan 22, 2020Pharmacology & Toxicology