Author

S. Thorpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. E. del Rio Hernandez· 1 shared A. J. Wood· 1 shared A. Mackinnon· 1 shared B. Gooptu· 1 shared B. Meyer· 1 shared C. Harris· 1 shared C. J. Hitchman· 1 shared C. Matellan· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBioengineering

A. E. del Rio Hernandez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intercomparison of growth models for Antarctic krill (Euphausia superba): towards a generalised understanding

D. Bahlburg, S. Thorpe, B. Meyer, U. Berger, E. Murphy

This study compares different growth models for Antarctic krill to assess their sensitivity to variables and highlights the importance of model structure and data in predicting krill growth.

bioRxiv · May 9, 2023 · PreprintEcology

CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

P. Stylianou, S. Rushwan, W. Wang, M. A. Miah, O. Darweesh, A. Mackinnon, K. M. Roach, C. J. Hitchman, O. Gonchar, S. Thorpe, C. Harris, R. Haigh, D. F. Richards, V. Snetkov, J. Beasley, , B. Gooptu

This study identifies CD98 as critical for inflammatory responses to injury stimuli in IPF exacerbations and COVID pneumonitis, showing its role in IL-6 and IL-8 responses and fibrosis progression.

bioRxiv · Aug 12, 2022 · PreprintCell Biology

Retinoid acid receptor β mechanically regulates the activity of pancreatic cancer cells

C. Matellan, D. Lachowski, E. Cortes, S. Thorpe, A. E. del Rio Hernandez

This study shows that RAR-β reduces cytoskeletal stiffness and invasion in pancreatic cancer cells by downregulating MLC-2.

bioRxiv · Aug 10, 2022Bioengineering

Genetic Screen in a Pre-Clinical Model of High-Grade Complex Karyotype Sarcoma Characterizes Drivers of Distinct Sarcoma Subtypes and Identifies New Therapeutic Vulnerabilities

M. A. Munoz, J. Freeland, E. O'Donnell, J. Langerman, J. Bergonio, J. Surarez-Navarro, M. Darrow, S. Thorpe, R. Randall, K. L. Carraway, O. Witte, T. Graeber, J. Carr-Ascher

This paper develops a pre-clinical model of high-grade complex karyotype sarcomas to identify subtype-specific drivers and therapeutic targets through genetic screening and transcriptomic analysis.

bioRxiv · Jun 13, 2022 · PreprintCancer Biology

Simulating the evolutionary trajectories of metabolic pathways for insect symbionts in the Sodalis genus

R. J. Hall, S. Thorpe, G. H. Thomas, A. J. Wood

The paper uses metabolic modeling and evolutionary algorithms to simulate the evolutionary trajectories of Sodalis glossinidius after internalization, showing gene loss impacts on evolved populations.

bioRxiv · Oct 25, 2019Evolutionary Biology