Author

S. Vazquez-Sanchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. W. Cleveland· 2 shared H. Yu· 2 shared J. R. Yates· 2 shared S. Lu· 2 shared A. Gladfelter· 1 shared A. Goginashvili· 1 shared C. Liu· 1 shared D. Singh· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

D. W. Cleveland

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2 papers

Recent·Most cited

Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

S. Lu, J. Hu, O. A. Arogundade, A. Goginashvili, S. Vazquez-Sanchez, J. K. Diedrich, J. Gu, J. Blum, S. Oung, H. Yu, J. Ravits, C. Liu, J. R. Yates, D. W. Cleveland

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

bioRxiv · Oct 14, 2021Cell Biology

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

H. Yu, S. Lu, K. Gasior, D. Singh, O. Tapia, S. Vazquez-Sanchez, D. Toprani, M. Beccari, J. R. Yates, S. Da Cruz, J. Newby, M. Larfaga, A. Gladfelter, E. Villa, D. W. Cleveland

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

bioRxiv · Mar 28, 2020 · PreprintCell Biology