D. W. Cleveland

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

This study shows that loss of stathmin-2 causes neurofilament-dependent axonal collapse, leading to motor and sensory deficits and denervation in mice.

Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome

The paper shows that mitotic tethering by MDC1, TOPBP1, and CIP2A enables en masse inheritance of chromothriptic chromosome fragments, contributing to cancer genome evolution.

Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

This study shows the SARS-CoV-2 N protein forms distinct condensates with RNA and M protein, aiding viral RNA packaging and virion assembly.

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.