Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
S. Lu, J. Hu, O. A. Arogundade, A. Goginashvili, S. Vazquez-Sanchez, J. K. Diedrich, J. Gu, J. Blum, S. Oung, H. Yu, J. Ravits, C. Liu, J. R. Yates, D. W. Cleveland
This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.
bioRxiv · Oct 14, 2021Cell Biology