Inosine is an alternative carbon supply that supports effector T cell proliferation and anti-tumor function under glucose restriction
T. Wang, J. R. Gnanaprakasam, X. Chen, S. Kang, X. Xu, H. Sun, L. Liu, E. Miller, T. A. Cassel, Q. Sun, S. Vicente-Munoz, M. O. Warmoes, A. N. Lane, X. Song, T. W.- M. Fan, R. Wang
This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.
bioRxiv · Sep 14, 2019 · PreprintImmunology