S. Victoria

CD4+ T cells facilitate replication of primary HIV-1 strains in macrophages and formation of macrophage internal virus-containing compartments.

This study shows that non-infected CD4+ T cells enhance replication of primary HIV-1 in macrophages and promote formation of virus-containing compartments (VCCs).

Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

This paper develops a nanoparticle formulation of BayK8644 that enhances its anti-tumoral efficacy by separating its dual effects on innate and adaptive immunity.