Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma 3D organoids and identify matrix-activated therapeutic targets
R. Cruz-Acuna, S. W. Kariuki, K. Sugiura, C. Loebel, T. Karakasheva, J. T. Gabre, J. A. Burdick, A. K. Rustgi
The paper develops a hydrogel platform to study matrix mechanics in EAC organoids and identifies therapeutic targets for ECM stiffness.
bioRxiv · Nov 13, 2022 · PreprintBioengineering