Author

S. Yakar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Yildirim· 3 shared S. B. Poudel· 3 shared D. Harrison· 2 shared M. Dixit· 2 shared R. Strong· 2 shared B. Brukner Dabovic· 1 shared C. Alexandre· 1 shared C. Lu· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPathology

G. Yildirim

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Author profile →

4 papers

Recent·Most cited

Deletion of absent in melanoma (AIM) 2 gene alters bone morphology

Z. Gong, M. Dixit, S. B. Poudel, G. Yildirim, S. Yakar, R. Muzumdar

This study investigates the impact of AIM2 gene deletion on bone morphology in mice, finding increased cortical thickness and decreased trabecular bone volume and BMD in aged AIM2 null females.

bioRxiv · Jan 5, 2024 · PreprintPathology

Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

S. B. Poudel, R. R. Raff, G. Yildirim, R. Miller, D. Harrison, R. Strong, T. Kirsch, S. Yakar

This study examines primary osteoarthritis in aged UM-HET3 mice, finding sex-specific effects of MB and MitoQ treatments and correlations between cartilage scores and inflammation, cell cycle markers, and subchondral bone changes.

bioRxiv · Dec 16, 2023Pathology

Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging

S. B. Poudel, D. F. Benayed, R. R. Ruff, G. Yildirim, M. Dixit, M. B. Schaffler, R. Korstanje, L. Robinson, R. A. Miller, D. Harrison, R. Strong, S. Yakar

This study evaluates the effects of methylene blue and mitoquinone on skeletal aging in mice, finding no significant reduction in age-related bone loss despite some in vitro benefits.

bioRxiv · Jun 16, 2023Pharmacology & Toxicology

Membrane-type 1 matrix metalloproteinase (MMP-14) modulates tissue homeostasis by a non-proteolytic mechanism

M. G. Attur, C. Lu, X. Zhang, T. Han, C. Alexandre, C. Valacca, S. Zheng, S. Meikle, B. Brukner Dabovic, E. Tassone, Q. Yang, V. Kolupaeva, S. Yakar, S. B. Abramson, P. Mignatti

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

bioRxiv · Sep 1, 2020Cell Biology