R. Miller

Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

This study examines primary osteoarthritis in aged UM-HET3 mice, finding sex-specific effects of MB and MitoQ treatments and correlations between cartilage scores and inflammation, cell cycle markers, and subchondral bone changes.

Bacterial diversity and composition on the rinds of specific melon cultivars and hybrids from across different growing regions in the United States

This study characterizes bacterial diversity on melon rinds across US regions and identifies regional influences on microbiome composition.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

Social influences on delayed gratification in New Caledonian crows and Eurasian jays

This study examines how social context affects delayed gratification in New Caledonian crows and Eurasian jays, finding species differences in reward selection under varying social conditions.

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

This study shows male mice have worse joint damage and persistent synovial inflammation after ACLR injury compared to females.

From Pigs to Silkworms: Cognition and Welfare across 10 Farmed Taxa

The paper develops a cross-taxa framework to assess cognition and welfare ranges in farmed animals using behavioral and cognitive proxies.

Inline SAXS-coupled chromatography under extreme hydrostatic pressure

This study demonstrates that reproducible SEC-SAXS can be performed under extreme hydrostatic pressure up to 100 MPa, revealing pressure-induced changes in biomolecular structure and oligomeric state.

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

This study evaluates the activity of TPP8, a tricyclic pyrrolopyrimidine gyrase B inhibitor, against Mycobacterium abscessus in vitro, ex vivo, and in vivo.

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

This study designs and tests a chimeric fusion protein vaccine (RHMS-1) combining immunodominant epitopes from RSV and hMPV F proteins, showing protection against both viruses in mice.

Neophobia and innovation in critically endangered Bali myna, Leucopsar rothschildi

The paper tests neophobia and innovation in Bali myna to inform conservation strategies, finding context-dependent responses and individual repeatability.

Individual repeatability, species differences, and the influence of socio-ecological factors on neophobia in 10 corvid species

This study investigates neophobia in 10 corvid species, finding species differences and socio-ecological influences on novelty responses across 241 subjects in 10 labs.

Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus

This study shows that inactivating the posterior dorsomedial caudate-putamen impairs learning of a nicotine-sucrose association in rats, while the anterior region does not.

Genome-wide identification and characterization of Solanum tuberosum BiP genes reveals the role of the promoter architecture in BiP gene diversity

This study identifies and characterizes three BiP genes in potato, showing their expression patterns and promoter architecture differences linked to developmental and stress responses.

Optimal spatial prioritization of control resources for elimination of invasive species under demographic uncertainty

This study shows that optimal resource allocation for invasive species control depends on connectivity structure, damage function, and observational uncertainty, with improved monitoring being most beneficial under moderate budgets.

Decision-making flexibility in New Caledonian crows, young children and adult humans in a multi-dimensional tool-use task

This study compares decision-making flexibility in New Caledonian crows, children, and humans during a tool-use task, finding differences in tool selection and adaptability to complexity.