Author

S.-H. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. J. R. Heck· 2 shared A. Antanasijevic· 1 shared A. J. Borst· 1 shared A. Khmelinskaia· 1 shared A. M. Watkins· 1 shared B. Basu Mallik· 1 shared C. Ogohara· 1 shared D. Baker· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

A. J. R. Heck

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2 papers

Recent·Most cited

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

A. Khmelinskaia, N. P. Bethel, F. Fatehi, A. Antanasijevic, A. J. Borst, S.-H. Lai, J. Y. Wang, B. Basu Mallik, M. M. Miranda, A. M. Watkins, C. Ogohara, S. Caldwell, M. Wu, A. J. R. Heck, D. Veesler, , N. P. King

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.

bioRxiv · Oct 18, 2023Bioengineering

Probing Affinity, Avidity, Anti-Cooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses

V. C. Yin, S.-H. Lai, T. G. Caniels, P. J. M. Brouwer, M. Brinkkemper, Y. Aldon, H. Liu, M. Yuan, I. A. Wilson, R. W. Sanders, M. van Gils, A. J. R. Heck

This study uses single particle mass analyses to examine antibody binding to the SARS-CoV-2 spike protein, revealing sub-stoichiometric binding and its effectiveness in blocking ACE2.

bioRxiv · Jun 18, 2021Immunology