A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of infective endocarditis
M. O. Gaytan, A. K. Singh, S. A. Woodiga, S. A. Patel, S.-S. An, A. Vera Ponce de Leon, S. McGrath, A. R. Miller, J. M. Bush, M. van der Linden, V. Magrini, R. K. Wilson, T. Kitten, S. J. King
This study identifies a novel sialic acid-binding adhesin, AsaA, in IE-causing bacteria that contributes to pathogenesis by binding platelets through sialic acid, expanding the known role of sialic acid as a receptor in bacterial-platelet interactions.
bioRxiv · Jul 17, 2020Microbiology