Author

S.-Y. Peak-Chew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

S. Munro· 3 shared J. Cattin-Ortola· 2 shared T. J. Stevens· 2 shared A. Borgeaud· 1 shared A. K. Gillingham· 1 shared B. Bisnett· 1 shared C. H. Lamb· 1 shared D. Gianni· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

S. Munro

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Author profile →

5 papers

Recent·Most cited

Cargo selective vesicle tethering: the structural basis for binding of specific cargo proteins by the Golgi tether component TBC1D23

J. Cattin-Ortola, J. G. G. Kaufman, A. K. Gillingham, J. L. Wagstaff, S.-Y. Peak-Chew, T. J. Stevens, D. J. Owen, S. Munro

The paper identifies a mechanism by which TBC1D23 recognizes transport vesicles destined for the Golgi through direct binding to a shared cargo motif.

bioRxiv · Nov 22, 2023Cell Biology

Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.

N. Gomez-Navarro, J. Maldutyte, K. Poljak, S.-Y. Peak-Chew, J. Orme, B. Bisnett, C. H. Lamb, M. Boyce, D. Gianni, E. A. Miller

The paper inhibits protein secretion by disrupting receptor-coat interactions, specifically targeting PCSK9 and other SURF4 clients without affecting other secreted proteins.

bioRxiv · Jan 31, 2022Cell Biology

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

L. G. Welch, S.-Y. Peak-Chew, F. Begum, T. J. Stevens, S. Munro

This study identifies GOLPH3 and GOLPH3L as broad-spectrum COPI adaptors that interact with diverse Golgi enzymes to regulate glycosylation pathways.

bioRxiv · Jun 18, 2021Cell Biology

Determining the content of vesicles captured by golgin tethers using LOPIT-DC

J. J. H. Shin, S. Munro, K. S. Lilley, O. M. Crook, A. Borgeaud, J. Cattin-Ortola, S.-Y. Peak-Chew, J. Chadwick

This study uses LOPIT-DC and Bayesian analysis to identify proteins on vesicles captured by golgins, revealing their retrograde transport nature and cargo composition.

bioRxiv · Nov 14, 2019 · PreprintCell Biology

Akt kinases are required for efficient feeding by macropinocytosis in Dictyostelium

T. D. Williams, P. Paschke, S.-Y. Peak-Chew, R. R. Kay

The paper shows Akt kinases are essential for efficient fluid uptake via macropinocytosis in Dictyostelium by increasing macropinosome size.

bioRxiv · Sep 14, 2018Cell Biology