S. Munro

The FAM114A proteins are adaptors for the recycling of Golgi enzymes

This study identifies FAM114A proteins as adaptors that bind Golgi enzymes and contribute to COPI vesicle recycling specificity in the Golgi stack.

Tracking exocytic vesicle movements reveals the spatial control of secretion in epithelial cells.

The paper tracks exocytic vesicle movements in epithelial cells to show microtubule organisation controls apical secretion and reveals spatially organised ECM secretion.

Cargo selective vesicle tethering: the structural basis for binding of specific cargo proteins by the Golgi tether component TBC1D23

The paper identifies a mechanism by which TBC1D23 recognizes transport vesicles destined for the Golgi through direct binding to a shared cargo motif.

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

This study identifies GOLPH3 and GOLPH3L as broad-spectrum COPI adaptors that interact with diverse Golgi enzymes to regulate glycosylation pathways.

A cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1

The paper presents a cryo-EM structure of Drosophila TRAPPIII, revealing how its large subunits interact with the core to regulate Rab1 activation and providing insights into its evolutionary relationship with TRAPPII.

Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

This study identifies cytoplasmic tail sequences in SARS-CoV-2 Spike that facilitate surface expression and syncytia formation by interacting with cellular factors like COPI, COPII, and ERM proteins.

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

Determining the content of vesicles captured by golgin tethers using LOPIT-DC

This study uses LOPIT-DC and Bayesian analysis to identify proteins on vesicles captured by golgins, revealing their retrograde transport nature and cargo composition.

In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

The paper introduces MitoID, a method to identify GTPase effectors and regulators using mitochondrial relocalization and proximity biotinylation, validating novel interactors for Rab, Rho, and Ras family GTPases.