Author

J. L. Wagstaff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Assay:electronic health records· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

S. H. McLaughlin· 2 shared S. M. Freund· 2 shared A. Berndt· 1 shared A. Boland· 1 shared A. G. Murzin· 1 shared A. K. Gillingham· 1 shared A. Kotecha· 1 shared C. King· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

S. H. McLaughlin

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Author profile →

4 papers

Recent·Most cited

Cargo selective vesicle tethering: the structural basis for binding of specific cargo proteins by the Golgi tether component TBC1D23

J. Cattin-Ortola, J. G. G. Kaufman, A. K. Gillingham, J. L. Wagstaff, S.-Y. Peak-Chew, T. J. Stevens, D. J. Owen, S. Munro

The paper identifies a mechanism by which TBC1D23 recognizes transport vesicles destined for the Golgi through direct binding to a shared cargo motif.

bioRxiv · Nov 22, 2023Cell Biology

Disease-specific tau filaments assemble via polymorphic intermediates

S. Lövestam, D. Li, J. L. Wagstaff, A. Kotecha, D. Kimanius, S. H. McLaughlin, A. G. Murzin, S. M. V. Freund, M. Goedert, S. H. W. Scheres

This study uses cryo-EM to analyze intermediate structures in tau filament assembly, revealing shared and condition-dependent intermediates in Alzheimer's and CTE pathogenesis.

bioRxiv · Jul 24, 2023Biophysics

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

J. Nixon-Abell, F. S. Ruggeri, S. Qamar, T. W. Herling, M. A. Czekalska, Y. Shen, G. Wang, C. King, M. S. Fernandopulle, T. Sneideris, J. L. Watson, V. V. Pillai, W. Meadows, J. Henderson, J. E. Chambers, , P. St George Hyslop

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

bioRxiv · Mar 22, 2023Cell Biology

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

R. L. Williams, M. Heimhalt, A. Berndt, J. L. Wagstaff, M. Anandapadamanaban, O. Perisic, S. Maslen, S. H. McLaughlin, C. W.-H. Yu, G. R. Masson, A. Boland, X. Ni, K. Yamashita, G. N. Murshudov, M. Skehel, S. M. Freund

This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.

bioRxiv · Apr 28, 2021Biochemistry