Intensive Chemotherapy Induces Cardiotoxicity via Reverse Electron Transport
Carla Pinto, Youzhong Liu, Sabrina Benaouadi, Yannis Sainte–Marie, Lotfi Laaouamir, Dimitri J. Marsal, Nick van Gastel, Frédérique Savagner, Thomas Farge
This study shows malonate prevents chemotherapy-induced cardiotoxicity by inhibiting mitochondrial reverse electron transport, preserves cardiac function, and sensitizes AML cells to intensive chemotherapy.
bioRxiv · Dec 20, 2024 · PreprintPathology