Nick van Gastel

LuCEMe: An accessible luciferase-based method to functionally assess cellular metabolism across model systems

LuCEMe is a luciferase-based method to assess cellular metabolism in various systems, revealing metabolic differences in cancer and immune cell interactions.

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy

This study investigates the role of EAAT1 in AML cell growth and therapy response, finding that EAAT1 inhibition does not impair AML growth or chemosensitivity.

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

Intensive Chemotherapy Induces Cardiotoxicity via Reverse Electron Transport

This study shows malonate prevents chemotherapy-induced cardiotoxicity by inhibiting mitochondrial reverse electron transport, preserves cardiac function, and sensitizes AML cells to intensive chemotherapy.