PathologybioRxivPreprint
Intensive Chemotherapy Induces Cardiotoxicity via Reverse Electron Transport
Carla Pinto, Youzhong Liu, Sabrina Benaouadi…·Thomas Farge
This study shows malonate prevents chemotherapy-induced cardiotoxicity by inhibiting mitochondrial reverse electron transport, preserves cardiac function, and sensitizes AML cells to intensive chemotherapy.
DOI 10.1101/2024.12.20.629711