Retrotransposons Promote Dnmt3a-Mutant Clonal Hematopoiesis Through Aging-Related Stromal Inflammation
Qiongdi Zhang, Wenhuo Hu, Joshua Theriot, Michael Lee, Sabrina Rinaldi, Yoon Jung Kim, Donghong Cai, Kathryn E. Dickerson, Jennifer J. Trowbridge, Nan Yan, Jian Xu, Sisi Zheng
This study shows that aging-related retrotransposon activation in stromal cells promotes Dnmt3a-mutant clonal hematopoiesis through inflammation.
bioRxiv · Jul 2, 2026 · PreprintCancer Biology