Jian Xu

This study shows that aging-related retrotransposon activation in stromal cells promotes Dnmt3a-mutant clonal hematopoiesis through inflammation.

The paper shows that LACTB2 in the liver regulates mitochondrial maturation to coordinate carbohydrate metabolism with brain development in mice.

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

This study identifies key sequence patterns that determine transcription initiation in human promoters using deep learning and experimental validation, showing conservation across mammalian species.

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.

MAnorm2 is a tool for comparing ChIP-seq samples across groups, improving differential binding detection by accounting for within-group variability and outperforming existing methods.

This paper introduces enhanced CRISPR epigenetic editing systems to analyze enhancer function in vivo, showing improved modulation of gene transcription with minimal off-target effects.

The paper shows that enhancer-dependence of gene expression increases with developmental age in mouse and human cells.

The paper identifies hub enhancers within super-enhancers using Hi-C and ChIP-seq data, showing their role in gene activation and chromatin structure.