The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses
Shixin Cui, Nicole L. Batenburg, Yan Coulombe, Aruna Arumugam, John R. Walker, Sadaf Valeh Sheida, Anja‐Katrin Bielinsky, M.C. Wahl, Jean‐Yves Masson, Xu‐Dong Zhu
This study identifies ASCC3 as a helicase that unwinds DNA at stalled replication forks, promoting fork reversal and preventing genomic instability during replication stress.
bioRxiv · Jul 24, 2025 · PreprintMolecular Biology