Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types
John P. McGinnis, Joshua Ortiz‐Guzman, Maria Camila Guevara, Sai Mallannagari, Benjamin D. W. Belfort, Suyang Bao, Snigdha Srivastava, Maria Morkas, Emily Ji, Angela Patricia Addison, Evelyne K. Tantry, Sarah Chen, Ying Wang, Zihong Chen, Kalman A. Katlowitz, , Benjamin Russell Arenkiel
This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.
Molecular Therapy — Methods & Clinical Development · May 21, 2025Peer-reviewedBioengineering