Joshua Ortiz‐Guzman

This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.

This study compares 11 AAV serotypes for transduction efficiency and specificity in murine olfactory sensory neurons using nasal inoculation.

The paper evaluates the transcriptional stability of cell types in ex vivo human brain tissue cultures over 14 days using single-nucleus RNA sequencing.

The paper introduces MAGIC, a cloning system enabling modular assembly of gene constructs for use in vertebrate models.

The paper identifies a glutamatergic circuit from the basal forebrain to the ventral tegmental area that reduces appetite and causes anorexia-like behaviors by decreasing dopamine release in the nucleus accumbens.

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.