Carrie Mohila

Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types

This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.

Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability

This study shows that mutant IDH impairs PDGFB's chromatin binding, leading to chromosome instability and accelerated gliomagenesis.

Cell type transcriptional identities are maintained in cultured ex vivo human brain tissue

The paper evaluates the transcriptional stability of cell types in ex vivo human brain tissue cultures over 14 days using single-nucleus RNA sequencing.