Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex
Murugesh Padmanarayana, Saira Sakalas, Parijat Sarkar, Mengxiao Ma, Ethan R. Garvin, Ethan N. Lee, Steven M. Corsello, Sebastian Guettler, Ganesh Varma Pusapati, Rajat Rohatgi
The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.
Nature Genetics · Jul 1, 2026Peer-reviewedBiochemistry