Author

Mengxiao Ma

Stanford MedicineORCID 0000-0003-4166-6004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:protein sequence· 1

Frequent Co-Authors

Ganesh Varma PusapatiiD· 2 shared Rajat RohatgiiD· 2 shared Annie JeniD· 1 shared Bharti SingaliD· 1 shared Ethan N. LeeiD· 1 shared Ethan R. GarviniD· 1 shared Evgenia ShishkovaiD· 1 shared Joshua J. CooniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Ganesh Varma PusapatiORCID

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2 papers

Recent·Most cited

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex

Murugesh Padmanarayana, Saira Sakalas, Parijat Sarkar, Mengxiao Ma, Ethan R. Garvin, Ethan N. Lee, Steven M. Corsello, Sebastian Guettler, Ganesh Varma Pusapati, Rajat Rohatgi

The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.

Nature Genetics · Jul 1, 2026Peer-reviewedBiochemistry

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface

Mengxiao Ma, Ramin Dubey, Annie Jen, Ganesh Varma Pusapati, Bharti Singal, Evgenia Shishkova, Katherine A. Overmyer, Valérie Cormier‐Daire, Juliette Fédry, L. Aravind, Joshua J. Coon, Rajat Rohatgi

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

Science · Nov 7, 2024Peer-reviewedCell Biology