Author
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA, USA;ORCID 0000-0001-9435-5600Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Shivali Rawat, Parijat Sarkar, Eric Giavedoni…·Rajat Rohatgi
The paper uses base editing screens to identify second-site mutations that correct misfolded NPC1 proteins, enabling therapeutic applications for diseases like Niemann-Pick type C.
Murugesh Padmanarayana, Saira Sakalas, Parijat Sarkar…·Rajat Rohatgi
The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.
Chris E. Williams, Laura Margaret Nocka, George Hedger…·Rajat Rohatgi
The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.