Author
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA, USA;ORCID 0000-0001-5057-9856Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Shivali Rawat, Parijat Sarkar, Eric Giavedoni…·Rajat Rohatgi
The paper uses base editing screens to identify second-site mutations that correct misfolded NPC1 proteins, enabling therapeutic applications for diseases like Niemann-Pick type C.
Murugesh Padmanarayana, Saira Sakalas, Parijat Sarkar…·Rajat Rohatgi
The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.
Manindra Bera, Kirill S. Grushin, Ramalingam Venkat Kalyana Sundaram…·Jeremy S. Dittman
This study shows that two Munc13 oligomers are essential for vesicle docking and SNARE assembly, supporting neurotransmitter release.