Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion
Tarun N. Bhatia, Saisrinidhi Ganta, Mostafa Meselhe, Caitlin Sojka, Antoni Andreu Martija, Lisa Nieland, Uriel Rufen-Blanchette, Anson David Sing, Alexia Tyler King, Brain Organoid Hub, Aparna Bhaduri, Kimberly Bojanowski Hoang, Edjah Kweku-Ebura Nduom, Renee D Read, Jeffrey J. Olson, Steven A. Sloan
This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.
bioRxiv · Oct 15, 2025 · PreprintNeuroscience