Antoni Andreu Martija

Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity

This study shows that glutamatergic neuron-tumor synapses influence glioblastoma cell states by modulating radial glia plasticity and transcriptional programs.

Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex

The paper identifies YBX1 as a key transcription factor in shaping human prefrontal cortex molecular identity through CRISPR activation screens and organoid experiments.

A Human Tumor-Immune Organoid Model of Glioblastoma

Autologous co-culture of patient glioblastoma cells and matched peripheral blood mononuclear cells in human cortical organoids (iHOTT) preserves tumor-immune crosstalk and recapitulates patient T cell responses to pembrolizumab.

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.

Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis

This study shows thalamic NRXN1 signaling promotes human cortical upper-layer neurogenesis by interacting with outer radial glia.

A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification

The paper integrates seven single-cell transcriptomic datasets to generate 225 meta-modules, identifying key gene networks involved in human cortical cell subtype specification and validating their roles in neurodevelopment.

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions

The paper identifies the pentose phosphate pathway's role in regulating radial glia cell fate during human cortical development using metabolic assays and genetic manipulations.

A neurovascular progenitor sits at the nexus of glioblastoma lineage trajectories

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.