Anson David Sing

Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation

This paper identifies a novel mechanism by which manganese disrupts mitochondrial transcriptome processing, leading to dsRNA accumulation and neuroinflammation through MDA5 activation.

Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation

This study shows human astrocytes can present antigens via MHCII after chronic cytokine exposure, revealing their potential as antigen-presenting cells.

Convergent effects of neurodevelopmental disorder-associated variants at mitochondria

The paper investigates how neurodevelopmental disorder-associated variants affect mitochondrial proteins and finds convergent effects on mitochondrial translation in two high-risk CNVs.

Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.

Lead (Pb) exposure alters neural cell fate in the developing human brain

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

The gamma-Protocadherins regulate the survival of GABAergic interneurons during developmentally-regulated cell death.

This study shows that gamma-Protocadherins are essential for the survival of GABAergic interneurons during development, preventing excessive apoptosis and ensuring proper inhibitory network formation.