Asparagine endopeptidase cleaves tau at N167 after uptake into microglia
Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C. Schöndorf, Michael Wolf, Salma A. Fahim, Enrico Murolo, Dagmar E. Ehrnhoefer
The paper identifies a novel tau cleavage site at N167 by AEP in microglia, showing it is part of a proteolytic cascade leading to tau degradation, not accumulation.
Neurobiology of Disease · Jun 21, 2019Peer-reviewedNeuroscience