David C. Schöndorf

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

SETD7-mediated lysine monomethylation is abundant on non-hyperphosphorylated nuclear Tau

The paper identifies lysine monomethylation on Tau by SETD7 in human brain tissue and shows its association with nuclear Tau in a mouse model of tauopathy.

Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

This study shows that IFN-γ and LRRK2 synergize in human neurons and microglia, leading to defects in neurite elongation and microglial activation.

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

The paper identifies specific phosphorylation sites on soluble tau oligomers in early Alzheimer’s disease that differ from those in neurofibrillary tangles.

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

The paper identifies a novel tau cleavage site at N167 by AEP in microglia, showing it is part of a proteolytic cascade leading to tau degradation, not accumulation.