Pathogenic T-bet+ memory B cells worsen multiple sclerosis through myeloid cell activation
Rajiv W. Jain, Maria Goiko, Antonio Mendes, Sara Xue, Salma Zein, Rianne Petra Gorter, Marlene Thorsen Mørch, Alexandre Prat, Rui Li, Voon Wee Yong
This study identifies T-bet+ memory B cells as pathogenic in MS by activating microglia/macrophages via IFN-γ, worsening EAE and demyelination.
bioRxiv · Sep 5, 2026 · PreprintImmunology