Voon Wee Yong

This study identifies T-bet+ memory B cells as pathogenic in MS by activating microglia/macrophages via IFN-γ, worsening EAE and demyelination.

The paper uses multiplex immunohistochemistry to show that fibroblast-associated vessels are increased in chronic active MS lesions and are linked to immune cell cuffs.

This study shows that fibroblasts accumulate in demyelinated spinal cord lesions in mice, excluding oligodendrocyte precursor cells, and this effect is more pronounced with age.

This study investigates EZHIP mutations in pediatric brain tumors, showing their presence in new tumor types and revealing their role in neuronal-like gene programs and polyamine metabolism repression.

The paper investigates microglial dynamics and modulation in MS models using siponimod, showing reduced neuronal damage and changes in microglial markers.

This study identifies elevated extracellular matrix molecules, particularly neurocan, in murine and human intracerebral hemorrhage, which inhibit oligodendrocyte precursor cell function and may impair repair.

This study shows that early life stress from animal transportation worsens experimental autoimmune encephalomyelitis in mice, supporting a two-hit model for multiple sclerosis etiology.

This study shows female mice have greater EAE susceptibility, higher cutaneous temperature, and sex-specific inflammatory responses compared to males.