Author

Samuel Cooke

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam LyoniD· 1 shared Adam RosenthaliD· 1 shared Erdal ToprakiD· 1 shared Muhammed Sadik YildiziD· 1 shared Scott H. SaundersiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

Adam LyonORCID

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1 paper

Recent·Most cited

Recurrent Extinction of Resistance Mutations Leads to Convergent Multidrug Resistance in Sequential Antibiotic Treatment

Adam Lyon, Muhammed Sadik Yildiz, Samuel Cooke, Scott H. Saunders, Adam Rosenthal, Erdal Toprak

The paper shows that sequential antibiotic treatment leads to convergent multidrug resistance through extinction of resistance mutations, with single-cell RNA sequencing revealing metabolic and translational state changes.

bioRxiv · Apr 8, 2025 · PreprintMicrobiology