Author

Adam Lyon

The University of Texas Southwestern Medical CenterORCID 0000-0002-2183-5993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam RosenthaliD· 1 shared Erdal ToprakiD· 1 shared Muhammed Sadik YildiziD· 1 shared Samuel Cooke· 1 shared Scott H. SaundersiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

Adam RosenthalORCID

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1 paper

Recent·Most cited

Recurrent Extinction of Resistance Mutations Leads to Convergent Multidrug Resistance in Sequential Antibiotic Treatment

Adam Lyon, Muhammed Sadik Yildiz, Samuel Cooke, Scott H. Saunders, Adam Rosenthal, Erdal Toprak

The paper shows that sequential antibiotic treatment leads to convergent multidrug resistance through extinction of resistance mutations, with single-cell RNA sequencing revealing metabolic and translational state changes.

bioRxiv · Apr 8, 2025 · PreprintMicrobiology