The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
Junsheng Chen, Megan C. Yap, Arthur Bassot, Danielle M. Pascual, Tadashi Makio, Jannik Zimmermann, Heather Mast, Rakesh Kumar Bhat, Samuel G. Fleury, Yuxiang Fan, Adriana Zardini Buzatto, Jack Moore, Klaus Ballanyi, Liang Li, Michael Overduin, , Thomas Simmen
This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.
Cell Reports · Oct 31, 2025Peer-reviewedCell Biology