Author

Thomas Simmen

University of AlbertaORCID 0000-0002-2350-2965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Klaus BallanyiiD· 2 shared Adriana Zardini BuzattoiD· 1 shared Ana CatuneanuiD· 1 shared Arthur BassotiD· 1 shared Bradley J. KerriD· 1 shared Bruce MorganiD· 1 shared Danielle M. PascualiD· 1 shared G. M. S. Mancini· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Klaus BallanyiORCID

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Author profile →

2 papers

Recent·Most cited

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

Junsheng Chen, Megan C. Yap, Arthur Bassot, Danielle M. Pascual, Tadashi Makio, Jannik Zimmermann, Heather Mast, Rakesh Kumar Bhat, Samuel G. Fleury, Yuxiang Fan, Adriana Zardini Buzatto, Jack Moore, Klaus Ballanyi, Liang Li, Michael Overduin, , Thomas Simmen

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

Cell Reports · Oct 31, 2025Peer-reviewedCell Biology

ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis

Muhammad Saad Yousuf, Samira Samtleben, Shawn M. Lamothe, Timothy N. Friedman, Ana Catuneanu, Kevin C. Thorburn, Mansi Desai, Gustavo Tenorio, Geert J. Schenk, Klaus Ballanyi, Harley T. Kurata, Thomas Simmen, Bradley J. Kerr

This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.

bioRxiv · Jan 22, 2020 · PreprintNeuroscience