Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Enrico Bagnoli, Yu‐En Lin, Sophie Burel, Ebsy Jaimon, Odetta Antico, Christos Themistokleous, Jonas M. Nikoloff, Samuel Squires, Ilaria Morella, Jens O. Watzlawik, Fabienne C. Fiesel, Wolfdieter Springer, Francesca Tonelli, Paweł Lis, Simon P. Brooks, , Miratul M. K. Muqit
This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.
Proceedings of the National Academy of Sciences · Jan 28, 2025Peer-reviewedBiochemistry