Longitudinal neuromelanin changes in prodromal and early Parkinson's disease in humans and rat model
J. Pérot, Anthony Ruze, Rahul Gaurav, Sana Rebbah, Capucine Cadin, Arnaud Le Troter, Lucas Soustelle, Laura Mouton, Romain Valabrègue, Annabelle Parent, Graziella Mangone, François‐Xavier Lejeune, Isabelle Arnulf, Jean‐Christophe Corvol, Marie Vidailhet, , Stéphane Lehéricy
The paper uses NM-sensitive MRI to study neuromelanin accumulation and neurodegeneration in Parkinson's disease models, finding a biphasic signal change linked to a pathogenic threshold.
Brain Communications · Jan 1, 2025Peer-reviewedNeuroscience